Package index

Main workflow

formatArguments() makeITT() print(<ConcreteArgs>)

formatArguments

doConcrete() print(<ConcreteEst>) plot(<ConcreteEst>) print(<ConcreteOut>)

doConcrete

getOutput() plot(<ConcreteOut>)

getOutput

getTmleDiagnostics()

Extract TMLE convergence diagnostics

RCT estimands

getRMST()

Restricted mean survival time and cause-specific life-years lost

targetRMST()

Directly target the restricted mean survival time

getRelativeEfficiency()

Relative efficiency of a covariate-adjusted vs unadjusted analysis

getWinRatio()

Covariate-adjusted restricted win ratio, win odds, and net benefit

targetWinRatio()

Directly targeted win ratio, win odds, and net benefit

clinicalWinRatio()

Hierarchical (death-priority) clinical win ratio (experimental)

clinicalPSNB()

Priority-standardized net benefit and win ratio (charter-weighted)

getRMTIF()

Restricted mean time in favor of treatment (first-event competing risks)

clinicalRMTIF()

Clinical (death-priority) restricted mean time in favor of treatment

getSimultaneousFamily()

Joint simultaneous inference across a family of estimands

Estimand framework

makeEstimand() print(<ConcreteEstimand>) applyIntercurrentEvent()

Specify an ICH E9(R1) estimand and apply an intercurrent-event strategy

senseCensoring()

Tipping-point sensitivity analysis for informative censoring

getPositivityDx()

Positivity / inverse-weight diagnostics for a fitted estimate

Package overview

concrete-package concrete

One-step continuous-time Targeted Minimum Loss-Based Estimator (TMLE) for outcome-specific absolute risk estimands in right-censored survival settings with or without competing risks